THE UNIVERSITY OF WESTERN AUSTRALIA
FACULTY OF MEDICINE AND DENTISTRY

YEAR  2002

1. Batty, K.T., Ilett, K.F., Powell, S.M., Martin, J., Davis, T.M.E. Relative bioavailability of artesunate and dihydroartemisinin: investigations in the isolated perfused rat liver and in healthy Caucasian volunteers. American Journal of Tropical Medicine and Hygiene. 2002;66:130-136.

2. Beaman, J. Hackett, L.P., Luxton, G. Ilett, K.F. The influence of hemodialysis on leflunomide disposition in a patient with end-stage renal disease. Annals of Pharmacotherapy. 2002;36:75-77.

3. Begg, E.J. Duffull, S.B. Hackett, L.P. Ilett, K.F. Studying drugs in human milk: time to unify the approach. Journal of Human Lactation. 2002;18:323-332.

4. Butcher, N.J. Boukouvala, S. Sim, E. and Minchin, R.F. Pharmacogenetics of the arylamine N-acetyltransferases. The Pharmacogenomics Journal. 2002; 2:30-42.

5. Chakera, A. van Heerden, P.V. and van der Schaaf, A. Elective awake incubation in a patient with massive multiodular goite presenting for radioiodine treatment. Anaesthesia and Intensive Care. 2002;30:236-239.

6. Chee, F. Fernando, T. and van Heerden, P.V. Closed-loop control of blood glucose levels in critically ill patients. Anaesthesia and Intensive Care. 2002;30(3):295-308.

7. Croke, S. Buist, A. Hackett, L.P. Ilett, K.F. Norman, T.R. Burrows, G.D. Olanzapine excretion in human breast milk: estimation of infant exposure. International Journal of Neuropsychopharmacology. 2002;5:243-247.

8. Davis, P., Lay-Yee, R., Briant, R., Ali, W., Scott, A., and Schug, S.A. Adverse events in New Zealand public hospitals 1: Occurrence and impact. New Zealand Medical Journal. 2002;115(1167):271-179.

9. Davis, P., Lay-Yee, R., Fitzjohn, J. Hider, P., Briant, R., and Schug, S.A. Compensation for medical injury in New Zealand: Does ‘no fault’ increase the level of claims-making and reduce social and clinical selectivity? Journal of Health Politics, Policy and Law 2002;27(5):833-854.

10. Davis, P., Lay-Yee, R., Fitzjohn, J., Hider, P., Schug, S.A., Briant, R., and Scott, A. Co-morbidity and health outcomes in three Auckland hospitals. New Zealand Medical Journal 2002;115:211-216.

11. Davydova, N., Streltsov, V., Wilce, M., Liljas, A., Garber, M. L22 Ribosomal protein and effect of its mutation on ribosome resistance to erythromycin. Journal of Molecular Biology, 2002;322:635-644.

12. Dobson, J. Stewart, Z. and Martinac, B. Preliminary evidence for weak-field magnetic effect on mechanosensitive ion channel sub-conducting states in E. coli. Electromagnetic Biology and Medicine. 2002;21:89-95.

13. Dusci, L.J. Hackett, L.P. Fellows, L.M. Ilett, K.F. Determination of olanzapine in plasma by high performance liquid chromatography using ultraviolet detection. Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences. 2002 773:191-197.

14. Ernst, E., Bartu, A., Popescu, A., Ilett, K.F. Hansson, R. Plumley, N. Methadone-related deaths in Western Australia 1993-1999. Australian and New Zealand Journal of Public Health. 2002;26:364-370.

15. Goldie, R.G. Fernandes, L. and Rigby, P. Airway nerves: detection and visualization. Current Opinion in Pharmacology. 2002 2:273-277.

16. Gomersall, C.D. Joynt, G.M. Freebairn, R.C. Lai, C.K.W. and Oh, T.E. Oxygen therapy for hypercapnic patients with chronic obstructive pulmonary disease and acute respiratory failure: A randomized controlled pilot study. Critical Care Med. 2002;30(1):113-116.

17. Hackett, L.P. Dusci, L.J. Ilett, K.F. Chiswell, G.M. Optimising the hydrolysis of codeine and morphine glucuronides in urine. Therapeutic Drug Monitoring. 2002;24:652-657.

18. Hale, T.W. Kristensen, J.H. Hackett, L.P. Kohan, R. Ilett, K.F. Transfer of metformin into human milk. Diabetologia. 2002;45:1509-1514.

19. Henry, P.J., Mann, T.S., D’Aprile, A.C., Self, G.J. and Goldie, R.G. An endothelin receptor antagonist, SB217242, inhibits airways hyperresponsiveness in allergic mice. American Journal of Physiology: Lung Cellular and Molecular Physiology. (2002);283:L1072-L1078.

20. Ilett, K.F. Batty, K.T. Powell, S.M. Thu, L.T.A. Hung, C.H. Davis, T.M.E. Phuong, H.L. Phuong, B.D.A. Thien, H.V. Binh, T.Q. The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated malaria. British Journal of Clinical Pharmacology. 2002;53:23-30.

21. Ilett, K.F. Ethell, B.T. Maggs, J.L. Davis, T.M.E. Batty, K.T. Burchell, B. Binh, T.Q. Thu, L.T.A. Hung, N.C., Pirmohamed, M. Park, B.K. Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases. Drug Metabolism and Disposition. 2002;30:1005-1012.

22. Ilett, K.F. Kristensen, J.H. Hackett, L.P. Paech, M. Kohan, R. Rampono, J. Distribution of venlafaxine and its O-desmethylmetabolite in human milk and their effects in breastfed infants. British Journal of Clinical Pharmacology. 2002;53:17-22.

23. Judge, RK, Henry, PJ, D’Aprile, AC, Lynch, D, Jelinek, GA, Wilce, MCJ and Wilce, JA. Identification of PLA2 and alpha-neurotoxin proteins in the venom of pseudonaja affinis (dugite). Toxicology and Applied Pharmacology (2002);181:184-191.

24. Kloda A and Martinac B. Common evolutionary origins of MS channels in Archaea Bacteria and cell-walled eukaryotic organisms. Archaea 2002;1:35-44.

25. Kloda A and Martinac B. Mechanosensitive channels of Bacteria and Archaea share a common ancestral origin. European Biophysics Journal 2002;31:14-25.

26. Kristensen JH Hackett LP Kohan R Paech M Ilett KF. The amount of fluvoxamine in milk is unlikely to be a cause of adverse effects in breastfed infants. Journal of Human Lactation 2002;18:139-142.

27. Lam CF Sviri S Ilett KF van Heerden PV. Inhaled diazeniumdiolates (NONOates) as selective pulmonary vasodilators. Expert Opinion on Investigational Drugs 2002;11:897-909.

28. Lam CF van Heerden PV Sviri S Roberts BL Ilett KF. The effects Inhalation of a novel nitric oxide donor DETA/NO in a patient with severe hypoxaemia due to the acute respiratory distress syndrome. Anaesthesia and Intensive Care 2002;30:472-476.

29. Lam C-F Caterina P Filion P van Heerden PV and Ilett KF. The ratio of polymorphonuclear leucocytes (PMN) to non-PMN cells – a novel method of assessing acute lung inflammation. Experimental and Toxicologic Pathology 2002;54:187-191.

30. Lan RS Stewart GA and Henry PJ. Role of protease-activated receptors in airway function: a target for therapeutic intervention? Pharmacology & Therapeutics 2002;95: 239-257.

31. MacFarlane J and Paech MJ. Another Knotted Epidural Catheter. Anaesthesia and Intensive Care 2002;30:240-243.

32. Martinac B and Hamill OP. Gramicidin A channels can switch between stretch-activation and stretch-inactivation depending upon bilayer thickness. Proc. Natl. Acad. Sci. USA 2002;99:4308-4312.

33. Morris, R.G. Ilett, K.F. Tett, S.E. Ray, J.E. Fullinfaw, R.O. Cooke, R. and Cook, S. Cyclosporin Monitoring in Australasia: 2002 Update of Consensus Guidelines. Therapeutic Drug Monitoring. 2002;24:677-688.

34. Oakley, A.J., Prokop, Z., Bohac, M., Kmunicek, J., Jedlicka, T., Monincova, M., Kuta-Smatanova, I., Nagata, Y., Damborsky, J., Wilce, M.C.J. Exploring the structure and activity of Haloalkane dehalogenase from sphingomonas paucimobilis UT26: Evidence for product- and water-mediated inhibition. Biochemistry, 2002; 41:4847-4855.

35. Perozo, E. Kloda, A. Cortes, D.M. and Martinac, B. Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating. Nature Struct. Biol. 2002;9:696-703.

36. Perozo, E. Cortes, D.M. Sompornpisut, P. Kloda, A. and Martinac, B. Structure of MscL in the open state and the molecular mechanism of gating in mechanosensitive channels. Nature 2002;418:942-948.

37. Petcu, E., Schug, S.A. and Smith R.H. Clinical evaluation of onset of analgesia using pamidronate in metastatic bone pain. Journal of Pain and Symptom Management 2002;24(3):287-289.

38. Stanley-Cary, C.C. Harris, C. and Martin-Iverson, M.T. Differing effects of the cannabinoid agonist CP 55 940 in an alcohol or Tween 80 solvent on prepulse inhibition of the acoustic startle reflex in the rat. Behavioural Pharmacology 2002;13:15-28.

39. Ward, B.K. Allan, R.K. Mok, D. Temple, S.E. Taylor, P. Dornan, J. Mark, P.J. Shaw, D.J. Kumar, P. Walkinshaw, M.D. and Ratajczak, T. A structure-based mutational analysis of cyclophilin 40 identifies key residues in the core tetratricopeptide repeat domain that mediate binding to Hsp90*. The Journal of Biological Chemistry 2002;277,43:40799-40809.

40. Yeap, B.B., Voon, D.C., Vivian, J.P., McCulloch, R.K., Thomson, A.M., Giles, K.M., Czyzyk-Krzeska, M.F., Furneaux, H., Wilce, M.C.J., Wilce, J.A., Leedman, P.J. Novel binding of HuR and PolyC-binding protein to a conserved UC-rich motif within the 3'-Untranslated region of the androgen receptor messenger RNA. The Journal of Biological Chemistry 2002;277,30:27183-27192.

41. Schug, S.A., Thornton, M.C. Local anaesthetics, Side Effects of Drugs Annual 25. 2002;25:149-159

Abstracts

Archer, V.L. Burns, H.T.F. Gibbons, P.L. Ilett. K.F. and Batty, K.T. Induction of the hepatic glycuronidation of dihydroartemisinin Conference Proceedings Pharmaceutical Science Beyond the Genome: Harnessing the Potential Annual Conference of the Australasian Pharmaceutical Science Association Melbourne 8-11 December 2002.

Chee, F., Fernando, T., van Heerden, P.V., Closed-loop glucose control in critically ill patients using Continuous Glucose Monitoring System (CGMS) in real-time. IEEE Transactions on Information Technology in Biomedicine 2002;11(7):472-476.

D’Aprile, A.C. Fernandes, L.B. Rigby, P.J. and Goldie, R.G. Impact of parainfluenza-3 virus infection on endothelin receptor density and function in guinea pig airways. Clincial Science 2002;103(Suppl. 48) 3455-3485.

DeCampo, B.A., Goldie, R.G., Jeng, A.Y. and Henry, P.J., Role of endothelin-converting enzyme, chymase and neutral endopeptidase in the processing of bit ET-1, ET-1(1-21) and ET-1(1-31) in the trachea of allergic mice. Clinical Science 103 (suppl 48)353S-356S.

**Gibbons, P.L. Batty, K.T., Barrett, P.H.R. Davis, T.M.E. and Ilett, K.F. Development of a pharmacokinetic-pharmacodynamic model on dihydroartemisinin in murine malaris. Annual Conference of the Australian Pharmaceutical Science Association Melbourne December 8 – 11 2002 Poster No. 10 p 113.

Goldie, R.G., D’Aprile, A. Betts, R.J. and Fernandes, L.B. Enhanced ETA receptor-mediated contractile function is associated with reduced ETA receptor density in sheep bronchial explants maintained in culture. Clinical Science 2002;103(Suppl 48) 3495-3525.

Hackett, L.P. Ilett, K.F. Aljazaf, K. Hale, T.W., Hartmann, P.E. Mitoulas, L.R. and Kristensen, J.H. Pseudoephedrine – effects on milk production in women and estimation of infant exposure via breastmilk. Proceedings of the Australian Health & Medical Research Congress. Abstract No. 2150 Melbourne November 23-28 2002 ISSN 1447-6010.

Ilett, K.F., Fellows, L. Ahmad, F. Castle, D.J., Dusci, L.J. and Bulsara, M.K. Target plasma concentration effects relationships for olanzapine in schizophrenia. Proceedings of the Australian Health & Medical Research Congress Abstract No. 422 Melbourne November 23-28 2002 ISSN 1447-6010.

Jenkins, B., Tuffin, P., Choo, L. and Schug, S.A. The Quality assessment of inpatient opioid prescribing at Royal Perth Hospital, Abstract Book SHPA (WA) Branch Conference, Perth 2002:21

Jenkins, B., Tuffin, P., Loh, S. and Schug, S.A. The Quality Assessment of Inpatient Antiemetic prescribing at Royal Perth Hospital, Abstract Book SHPA (WA) Branch Conference, Perth 2002:27.

Lam, C.F., van Heerden, P.V. and Ilett, K.F. Inhaled Diethylenetriamine nitric oxide adduct (DETA/NO) in ARDS; from bench to bedside: the efficacy in an animal model of acute pulmonary hypertension. Chest 2002;122 (Suppl 4)112S-113S.

Lam, C.F., van Heerden, P.V. and Ilett, K.F. The effects of inhaled nonoates in an animal model of acute pulmonary hypertension. The 27th Australian and New Zealand Annual Scientific Meeting on Intensive Care, 8th Australian and New Zealand Paediatric and Neonatal Intensive Care Conference, Perth, October 2002.

Lam, C.F., van Heerden, P.V. and Ilett, K.F. The first use of nonoates, novel selective pulmonary vasodilators in patients with ARDS. The 27th Australian and New Zealand Annual Scientific Meeting on Intensive Care, 8th Australian and New Zealand Paediatric and Neonatal Intensive Care Conference, Perth, October 2002.

Lam, C.F., van Heerden, P.V. and Ilett, K.F. The safety of aerosolized DETA/NO after inhalation in piglets and rats. The 27th Australian and New Zealand Annual Scientific Meeting on Intensive Care, 8th Australian and New Zealand Paediatric and Neonatal Intensive Care Conference, Perth, October 2002.

Lam, C.F., van Heerden, P.V. and Ilett, K.F. A potential bronchodilator role for DETA/NO. The 27th Australian and New Zealand Annual Scientific Meeting on Intensive Care, 8th Australian and New Zealand Paediatric and Neonatal Intensive Care Conference, Perth, October 2002.

Lam, C.F., van Heerden, P.V. and Ilett, K.F. PMN Ratio – a novel method for measurement of acute lung injury and/or inflammation. The 27th Australian and New Zealand Annual Scientific Meeting on Intensive Care, 8th Australian and New Zealand Paediatric and Neonatal Intensive Care Conference, Perth, October 2002.

Lam, C.F., van Heerden, P.V. and Ilett, K.F. The first use of nonoates, novel selective pulmonary cadodilators in patients with ARDS. The 27th Australian and New Zealand Annual Scientific Meeting on Intensive Care, 8th Australian and New Zealand Paediatric and Neonatal Intensive Care Conference, Perth, October 2002.

Macdonald, A.G., Martinac, B. and Bartlett, D.H. High pressure experiments with the porins from the barophile Photobacterium profundum SS9. Trends in High Pressure Bioscience and Biotechnology. R. Hayashi (ed) pp 311-316 2002

Rucklidge, M.W.M. and Paech, M.J. Regional anaesthesia in parturients with low platelet counts. Int J Obstet Anesth 2002; 11(S):O10

Schug, S.A. Regional anaesthesia and outcome – cardiovascular and pulmonary implications, In Highlights in Pain Therapy and Regional Anaesthesia XI, pp 125-126, (Ed. Van Zundert, A and Rawal, N) ESRA and Cyprint, Cyprus, 2002.

Schug, S.A. Meta-analysis shows that neuraxial blocks reduce mortality and morbidity, In Highlights in Pain Therapy and Regional Anaesthesia XL, pp 329-331, (Ed. Van Zundert, A and Rawal, N) ESRA and Cyprint, Cyprus, 2002.

Schug, S.A. World congress explores approaches to management of pain. Commentary. Australian Journal of General Practice, 2002;2(5):13.

Schug, S.A. Current directions in acute pain management. Abstract Book 27th Australian and New Zealand ASM on Intensive Care, Perth 2002:50.

Reviews

Garrett, W., Gillespie, G. and Schug, S.A. Topical infusion of bupivacaine for analgesia after arthroscopic shoulder surgery. Summary and Comment. International Monitor of Regional Anaesthesia, 2002;14(3):21.

Gillespie, G., Onslow, J. and Schug, S.A. Thoracic epidural anaesthesia/analgesia in coronary artery bypass surgery. International Monitor of Regional Anaesthesis, 2002;14(1):13-14.

Paech, M.J. Epidural Pain Relief in Labour (video) Anaesth Intensive Care 2002; 30:707-708

Schug, S.A. Is neuropathic pain an acute problem? (Editorial) Acute Pain 2002;4(2):43.

Schug, S.A. Mechanisms and Mediators of Neuropathic Pain (Book Review) Acute Pain 2002;4(2):77

Books
Hale, T.W. Ilett, K.F. Drug therapy and breastfeeding; from theory to clinical practice. London: The Parthenon Publishing Group London 2002. ISBN 1-84214-110-4 (book 94 pages).

Book Chapter
Schug, S.A. and Cardwell, H.M.D. Clinical pharmacology – including tolerance, in Clinical Pain Management Cancer Pain, (Ed. Sykes, N, Fallon, MT and Patt, RB, London). Part 1, Chpt 3, 2002;33-62.

Schug, S.A. and Ritchie, J.E. Principles of oral analgesic therapy in cancer pain. in Clinical Pain Management Cancer Pain, (Ed. Sykes, N, Fallon, MT and Patt, RB, London). Part 2, Chpt 10, 2002; 123-141.

Schug, S.A. and Thornton, M.C. Local anesthetics. Side Effects of Drugs 2002;25:149-159.