THE UNIVERSITY OF WESTERN AUSTRALIA
FACULTY OF MEDICINE AND DENTISTRY

Professional Associations
Member, Pharmaceutical Society of Western Australia. 
Member, Australasian Society for Clinical and Experimental Pharmacologists and Toxicologists. 
Member, British Pharmacological Society. 
Member, International Society for the Study of Xenobiotics. 
Member, Western Australian Government Poisons Advisory Committee. 
Member of Review Panel for British Journal of Pharmacology, Pharmacogenetics & Addiction. 
Assessor, National Health and Medical Research Council. 

Recent publications

1. Ilett KF, Johnson S, Greenhill G, Mullen L, Brockis J, Golledge CL, Reid DB. Modification of general practitioner prescribing of antibiotics by use of a therapeutics adviser (academic detailer). British Journal of Clinical Pharmacology 2000; 49: 168-173.
2. Yapp P, Ilett KF, Kristensen JH, Hackett LP, Paech MJ, Rampono J. Drowsiness and poor-feeding in a breast-fed infant: association with nefazodone and its metabolites. The Annals of Pharmacotherapy 2000; 34:1269-1272.
3. Ilett KF, McCormick N, Carpenter DS, Spargo RM, LeSoeuf PN, Musk AW, Minchin RF. Genetic polymorphisms in glutathione S-transferase M1 and T1 in an Australian Aborigine population. Pharmacogenetics 2000; 10:477-480.
4. Rampono J, Kristensen JH, Hackett LP, Paech M, Kohan R, Ilett KF. Citalopram and demethylcitalopram in milk; distribution, excretion and effects in breastfed infants. British Journal of Clinical Pharmacology 2000; 50:263-268.
5. Hansen TG, Ilett KF, Li SI, Re C, Hackett LP, Bergesio R. Pharmacokinetics and clinical efficacy of long-term epidural ropivacaine infusion in children. British Journal of Anaesthesia 2000; 85:347-353.
6. Butcher NJ, Ilett KF, Minchin RF. Substrate-dependent loss of human arylamine N-acetyltransferase-1 in cultured cells results in down-regulation of enzyme activity. Molecular Pharmacology 2000; 57:468-473.
7. Davis TME, Daly F, Walsh JP, Ilett KF, Beilby JP, Dusci LJ, Barrett PHR. Pharmacokinetics and pharmacodynamics of gliclazide in Caucasians and Australian Aborigines with type 2 diabetes. British Journal of Clinical Pharmacolog y 2000; 49:223-230.
8. Hill RC, McIvor RJ, Wojnar-Horton RE, Hackett LP, Ilett KF. Risperidone distribution and excretion in human milk: case report and estimated infant exposure during breast-feeding. Journal of Clinical Psychopharmacology 2000; 20: 285-286.
9. Butcher NJ, Ilett KF, Minchin RF. The hydroxylamine of p-aminobenzoic acid inactivates human arylamine N-acetyltransferase-1 in cultured cells. Biochemical Pharmacology 2000; 60:1829-1836.
10. Agus C, Ilett KF, Kadlubar FF, Minchin RF. Characterisation of an ATP-dependent pathway of activation for the heterocyclic amine carcinogen N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline (N-OH-IQ). Carcinogenesis 2000; 21:1213-1219.
11. Griese E-U, Ilett KF, Kitteringham N, Eichelbaum M, Powell H, Spargo RM, LeSoeuf PN, Musk AW, Minchin RF. Genetic polymorphisms in CYP2D6, CYP2C19 and CYP 2E1 in Aborigines from Western Australia. Pharmacogenetics 2001; 11:69-76.
12. Davis TME, Batty KT, Thu LTA, Ilett KF, Hung NC, Powell SM, Thien HV, Binh TQ. Pharmacokinetics and pharmacodynamics of intravenous artesunate in severe falciparum malaria. Antimicrobial Agents and Chemotherapy 2001; 45: 181-186.
13. Binh TQ, Ilett KF, Batty KT, Davis TME, Hung NC, Powell SM, Thu LTA, van Thien H, Phuong HL, Phuong VDB. Oral bioavailability of dihydroartemisinin in Vietnamese volunteers and in patients with falciparum malaria. British Journal of Clinical Pharmacology 2001; 51:541-546.
14. Begg EJ, Malpass TJ, Hackett LP, Ilett KF. Distribution of R- and S-methadone into human milk at steady state during ingestion of medium to high doses. British Journal of Clinical Pharmacology 2001; 52:681-685.
15. Chan CF, Chiswell GM, Bencini R, Hackett LP, Dusci LJ, Ilett KF. Quantification of naltrexone and 6,?-naltrexol in plasma and milk using gas chromatography-mass spectrometry; application to studies in the lactating sheep. Journal of Chromatography B; 2001;761: 85-92.
16. Zhang S-Q, Hai TN, Ilett KF, Huong DX, Davis TME, Ashton M. Multiple dose study of interactions between artesunate and artemisinin in healthy volunteers. British Journal of Clinical Pharmacology 2001; 52: 377-385.
17. Hansen TG, Ilett KF, Reid C, Hackett LP, Bergesio R. Caudal ropivacaine in infants: population pharmacokinetics and plasma concentrations. Anesthesiology 2001; 94: 579-584.
18. Rose AH, Ilett KF, O’Donoghue HL, Hackett LP, Penhale WJ, Manning LS, Glancy RJ, Cullen LK, Turner HT. Cyclosporin immunosuppression of sheep: pharmacokinetics and allograft survival. Veterinary Immunology and Immunopathology 2001; 81: 23-36.
19. Chan V, Morris RA, Ilett KF, Tett S. Population pharmacokinetics of lamotrigine. Therapeutic Drug Monitoring 2001; 23:630-635.
20. Beaman J, Hackett, LP, Luxton G, Ilett KF. The influence of hemodialysis on leflunomide disposition in a patient with end-stage renal disease. Annals of Pharmacotherapy 2002;36: 75-77.
21. Ilett KF, Ethell BT, Maggs JL, Davis TME, Batty KT, Burchell B, Binh TQ, Thu LTA, Hung NC, Pirmohamed M, Park BK. Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases. Drug Metabolism and Disposition 2002; 30:1005-1012.
22. Ernst E, Bartu A, Popescu A, Ilett KF, Hansson R, Plumley N. Methadone-related deaths in Western Australia 1993-1999. Australian and New Zealand Journal of Public Health 2002; 26:364-370 .
23. Croke S, Buist A, Hackett LP, Ilett KF, Norman TR, Burrows GD. Olanzapine excretion in human breast milk: estimation of infant exposure. International Journal of Neuropsychopharmacology 2002; 5:243-247.
24. Ilett KF, Kristensen JH, Hackett LP, Paech M, Kohan R, Rampono J. Distribution of venlafaxine and its O-desmethylmetabolite in human milk and their effects in breastfed infants. British Journal of Clinical Pharmacology 2002; 53: 17-22.
25. Ilett KF, Batty KT, Powell SM, Thu LTA, Hung CH, Davis TME, Phuong HL, Phuong BDA, Thien HV, Binh TQ. The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated malaria. British Journal of Clinical Pharmacology 2002; 53:23-30.
26. Hackett LP, Dusci LJ, Ilett KF, Chiswell GM. Optimising the hydrolysis of codeine and morphine glucuronides in urine. Therapeutic Drug Monitoring 2002; 24:652-657.
27. Kristensen JH, Hackett LP, Kohan R, Paech M, Ilett KF. The amount of fluvoxamine in milk is unlikely to be a cause of adverse effects in breastfed infants. Journal of Human Lactation 2002; 18:139-142.
28. Batty KT, Ilett KF, Powell SM, Martin J, Davis TME. Relative bioavailability of artesunate and dihydroartemisinin: investigations in the isolated perfused rat liver and in healthy Caucasian volunteers. American Journal of Tropical Medicine and Hygiene 2002; 66:130-136.
29. Lam CF, van Heerden PV, Sviri S, Roberts BL, Ilett KF. The effects of a novel nitric oxide donor, DETA/NO in a patient with severe hypoxaemia due to the acute respiratory distress syndrome. Anaesthesia and Intensive Care 2002; 30:472-476.
30. Dusci LJ, Hackett LP, Fellows, LM, Ilett KF. Determination of olanzapine in plasma by high performance liquid chromatography using ultraviolet detection. Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences 2002; 773:191-197.
31. Lam CF, Caterina P, Filion P, van Heerden PV, Ilett KF. The ratio of polymorphonuclear leucocytes (PMN) to non-PMN cells– a novel method of assessing acute lung inflammation. Experimental and Toxicologic Pathology 2002; 54(3):187-192.
32. Hale TW, Kristensen JH, Hackett LP, Kohan R, Ilett KF. Transfer of metformin into human milk. Diabetologia 2002; 45:1509-1514.
33. Morris RG, Ilett KF, Tett SE, Ray JE, Fullinfaw RO, Cooke R, Cook S. Cyclosporin Monitoring in Australasia: 2002 Update of Consensus Guidelines. Therapeutic Drug Monitoring 2002; 24:677-688.
34. Fellows L, Ahmad F, Castle DJ, Dusci LJ, Bulsara MK, Ilett KF. Investigation of target plasma concentration-effect relationships for olanzapine in schizophrenia. Therapeutic Drug Monitoring 2003; 25:682-689.
35. Lam CF, van Heerden PV, Ilett KF, Caterina P, Filion P. Two aerosolized nitric oxide adducts as selective pulmonary vasodilators for acute pulmonary hypertension. Chest 2003; 123: 869-874.
36. Gardiner SJ, Kristensen JH, Begg EJ, Hackett LP, Wilson DA, Ilett KF, Kohan R, Rampono J. Transfer of olanzapine into human milk, calculated infant dose and effects in breastfed infants. American Journal of Psychiatry 2003; 160:1428-1431.
37. Lam CF, Caterina P, Filion P, van Heerden PV, Ilett KF. The safety of aerosolized diethylenetriamine nitric oxide adduct (DETA/NO) after single-dose administration to anesthetized piglets, and multiple-dose administration to conscious rats. Toxicology and Applied Pharmacology 2003; 190: 65-71.
38. Aljazaf K, Hale TW, Ilett KF, Hartmann PE, Mitoulas LR, Kristensen JH, Hackett LP. Pseudoephedrine - effects on milk production in women and estimation of infant exposure via breastmilk. British Journal of Clinical Pharmacology 2003;56:18-24.
39. Karunajeewa HA, Kemiki A, Alpers M, Lorry K, Batty KT, Ilett KF, Davis TME. Safety and therapeutic efficacy of artesunate suppositories for treatment of malaria in children in Papua New Guinea. Pediatric Infectious Diseases 2003; 22:251-256.
40. Davis TME, Syed D, Ilett KF, Barrett, PHR. Toxicity related to chloroquine treatment of resistant vivax malaria. Annals of Pharmacotherapy 2003; 37:526-529.
41. Kotecka BM, Rieckmann KH, Davis TME, Batty KT, Ilett KF. Comparison of bioassay and high performance liquid chromatographic assay of artesunate and dihydroartemisinin in plasma. Acta Tropica 2003; 87:371-375.
42. Davis TME, Ilett KF, Batty KTB, Chiswell GM, Agus C, Phuong HL, Phuong VDB, Binh TQ. Penetration of dihydroartemisinin into cerebrospinal fluid after administration of intravenous artesunate. Antimicrobial Agents and Chemotherapy 2003;47:368-370.
43. Hung T-Y, Davis TME, Ilett KF. Measurement of piperaquine in plasma by high-performance liquid chromatography with ultraviolet absorbance detection. Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences 2003; 791:73-101.
44. Page-Sharp M, Hale TW, Hackett LP, Kristensen JH, Ilett KF. Measurement of nicotine and cotinine in human milk by high-performance liquid chromatography with ultraviolet absorbance detection. Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences : 2003; 796:173-180.
45. Ilett KF, Hale TW, Page-Sharp M Kristensen JH, Kohan R, Hackett LP. Using nicotine patches in breastfeeding mothers - transfer of nicotine and cotinine into human milk. Clinical Pharmacology and Therapeutics 2003; 74:516-524.
46. Cox-Singh J, Lu HY, Davis TME, Ilett KF, Hackett LP, Matusop A, Singh B. Application of a multi-faceted approach to the assessment of treatment response in falciparum malaria: a study from Malaysian Borneo. International Journal for Parasitology 2003; 33:1545-1552.
47. Lam CF, Lan RS, van Heerden PV, Ilett KF, Henry PJ. Diethylenetriamine nitric oxide relaxes precontracted mouse tracheal smooth muscle. Clinical and Experimental Pharmacology and Physiology 2003; 30:709-711.
48. Hung T-Y, Davis TME, Ilett KF, Karunajeewa H, Hewitt S,, Denis MB, Lim C, Socheat D. Population pharmacokinetics of piperaquine in adults and children with uncomplicated falciparum or vivax malaria. British Journal of Clinical Pharmacology 2004; 57:253-262.
49. Ilett KF, Hackett LP, Kristensen JH, Vaddadi KS, Gardiner S, Begg EJ. Transfer of risperidone and 9-hydroxyrisperidone into human milk. Annals of Pharmacotherapy 2004; 38:273-276.
50. Batty KT, Ilett KF, Davis TME. Protein binding and ??? anomer ratio of dihydroartemisinin in vivo. British Journal of Clinical Pharmacology 2004;57:529-533
51. Rampono J, Proud S, Hackett LP, Kristensen JH, Ilett KF. A pilot study of newer antidepressant concentrations in cord and maternal serum and possible effects in the neonate. International Journal of Neuropsychopharmacology 2004;7: (in press 17 November, 2003).
52. Karunajeewa H, Lim C, Ilett KF, Hung TY, Denis MB, Soucheat D, Davis, TME. Safety evaluation of fixed combination piperaquine plus dihydroartemisinin (Artekin) in Cambodian children and adults with malaria. British Journal of Clinical Pharmacology 2004; 57:93-99.
53. Bishop LPD, Maggs JL, Batty KT, Dodd CC, Ilett KF, O’Neill PM, Edwards G, Park BK. Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene. Chemico-Biological Interactions 2003; 147:173-184.
54. Chan CF, Page-Sharp M, Kristensen JH, O’Neil G, Ilett KF. Transfer of naltrexone and its metabolite 6,?-naltrexol into human milk. Journal of Human Lactation 2004; (in press 28 January, 2004).
55. Lam CF, van Heerden PV, Blott J, Roberts B, llett KF. The selective pulmonary vasodilatation effects of inhaled DETA/NO, a novel slow-release nitric oxide donor, in ARDS – a pilot human trial. Journal of Critical Care 2004; 19:48-53.
56. Hien TT, Davis TME, Chuong LV, Ilett KF, Mai NTH, Chau TTH, Agus C, Chiswell GM, White NJ, Farrar J. Comparative pharmacokinetics of intramuscular artesunate and artemether in severe falciparum malaria. Antimicrobial Agents and Chemotherapy 2004; (revision submitted 1 October, 2003)
 
Other
 
Special skills: pill rolling, statistical analysis.